University of Hawaii Neuroscience and MRI Research Program

Research Team

Thomas Ernst, Ph.D.

Curriculum Vitae

Professor

Department of Medicine, John A. Burns School of Medicine, University of Hawai'i, 1356 Lusitana Street, University Tower, 7th Floor, Honolulu, HI 96813

Email: tmernst -AT- hawaii -DOT- edu
Phone: (808) 691-5153
Fax: (808) 585-5160

Education

1979-1983 Dept. of Physics, University of Freiburg, Freiburg (FRG)
1983-1985 Diploma Thesis in Physics, Division of High Energy Physics, Dept. of Physics, University of Freiburg (FRG)
1983-1985 Fellowship in 'High Energy Muon Scattering'
European muon collaboration (EMC), CERN, Geneva, CH
1987-1990 Ph.D. in Physics
University Hospital Freiburg (FRG), MR Center & University of Freiburg, Dept. of Physics

Professional Memberships

International Society of Magnetic Resonance in Medicine
American Academy of Neurology

Professional Experiences

June 04 - present Professor of Medicine
Department of Medicine
John A. Burns School of Medicine, University of Hawaii
Sep 00 - June 04 Full Scientist
Director, Medical Physics
Brookhaven National Laboratory
May 94 - Aug 00 Assistant Professor in Residence
Departments of Radiology and Neurology
UCLA School of Medicine
May 99 - 2001 Chairman
ISMRM Study Group on "Magnetic Resonance in Drug Research"
1996 - 1998 Member
Spectroscopy Tachnical Advisory Board
General Electric Medical Systems
Feb 93 - April 94 Senior Research Scientist
MR Center
University Hospital Freiburg, FRG
Oct 92 - Oct 93 Visiting Associate
California Institute of Technology, Pasadena, CA
Jan 91 - Jan 93 Post-Doctoral Fellow
Director: Brian D. Ross, M.D., Ph.D.
Huntington Medical Research Institutes, Pasadena, CA

Reviewer for Scientific Journals and Societies

Aging Clinical and Experimental Research
American Journal of Psychiatry
Annals of Neurology
Applied Magnetic Resonance
Archives of Neurology
Biological Psychiatry
Biological Psychiatry: Neuroimaging
IEEE Transactions on Medical Imaging
International Society of Magnetic Resonance in Medicine (ISMRM)
Journal of Magnetic Resonance
Journal of Neurochemistry
Liver Transplantation and Surgery
Magnetic Resonance in Medicine (MRM)
Magnetic Resonance Materials (MAG*MA)
Medical Physics
NeuroImage
Neurology
Psychopharmacology
The Breast

Reviewer for Grant Awarding Institutions

Feb 99 Reviewer for NIH/NINDS Special Emphasis Panel
April 99 Reviewer for NIH/NIMH Special Emphasis Panel
April 2000 Chair, NIH/NINDS Special Emphasis Panel
May 2001 Reviewer for DOE SBIR program
June 2001 Reviewer for NIMH Special Emphasis Panel
Jan 2002 Reviewer for NCRR Special Emphasis Panel
June 2002 Reviewer, "Neuroimaging technology development to assess brain and behavior in pediatric populations" initiative.

Selected Peer-Reviewed Publications

Ernst T, Hennig J, Ott H: The importance of the voxel size in clinical spectroscopy of the human brain. NMR Biomed 2:216-224, 1989.

Ernst T, Hennig J: Double-volume 1H spectroscopy with interleaved acquisitions using tilted gradients. Magn Res Med 20:27-35, 1991.

Ernst T, Hennig J: Coupling effects in volume selective 1H spectroscopy of major brain metabolites. Magn Res Med 21:82-96, 1991.

Ernst T, Ross B, Flores R: Cerebral MRS in infant with suspected Reye's Syndrome. The Lancet 340:486, 1992.

Hennig J, Pfister H, Ernst T, Ott D: Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy. NMR Biomed 5:193-199, 1992.

Ernst T, Kreis R, Ross BD: Absolute quantitation of water and metabolites in the human brain; Part I: compartments and water. J Magn Res B102:1-8, 1993.

Kreis R, Ernst T, Ross BD: Absolute quantitation of water and metabolites in the human brain; Part II: metabolite concentrations. J Magn Res B102:9-19, 1993.

Kreis R, Ernst T, Ross BD: Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Res Med 3:424-437, 1993.

Miller B.L, Moats R, Shonk T, Ernst T, Wooley S, Ross B.D, Alzheimer Disease: Depiction of Increased Cerebral Myo-Inositol with Proton MR Spectroscopy Radiology 187, 433 – 437, 1993.

Ernst T, Lee JH, Ross BD: Direct 31P imaging in human limb and brain. J Comp Assist Tomogr 17:673-680, 1993.

Ernst T, Hennig J: Observation of a fast response in functional MR. Magn Res Med 31:146-149, 1994.

Ernst T, Hennig J: Improved water suppression for localized in vivo 1H spectroscopy. J Magn Res B106:181-186, 1995.

Chang L, Ernst T, Poland RE, Jenden DJ: In vivo proton magnetic resonance spectroscopy of the normal aging human brain. Life Sci 58:2049-2056,1996.

Ernst T, Chang L: Elimination of artifacts in short echo time 1H MR spectroscopy of the frontal lobe. Magn Reson Med 36:462-468,1996.

Ernst T, Chang L, Melchor R, Mehringer C.M, Fronto-Temporal Dementia and Early Alzheimer Disease: Differentiation with Frontal Lobe 1H MR Spectroscopy. Radiology 203, 829-836, 1997.

Itti L, Chang L, Mangin JR, Darcourt J, Ernst T: Robust multimodality registration for neuroimaging. Human Brain Mapping 5: 3-17,1997.

Ernst T, Chang L, Melchor R: Fronto-temporal dementia and early Alzheimer Disease: Differentiation with frontal lobe 1H MR spectroscopy. Radiology 203: 829-836,1997.

Itti L, Chang L, Ernst T, Mishkin F: High-resolution 3D correction for partial volume effects in functional neuroimaging. Human Brain Mapping 5: 379-388,1997.

Chang L, Ernst T, Osborn D, Seltzer W, Leonido-Yee M, Poland R: Correlation of cerebral metabolite abnormalities with trinucleotide repeats in myotonic dystrophy. Archives of Neurology, 1998; 55:305-311.

Ernst T, Chang L, Itti L, Speck, O, Correlation of regional cerebral blood flow from perfusion MRI and SPECT in normal subjects, Magnetic Resonance Imaging 1999;17(3):349-354.

Ernst T, Chang L, Witt M, Aronow H, Cornford M, Walot I, McBride D, Goldberg M: Cerebral toxoplasmosis and lymphoma in AIDS: Perfusion MR imaging experience in 13 patients. Radiology 1998;208(3):663-669.

Chang L, Ernst T, Leonido-Yee M, Walot I, Singer E. Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex. Neurology 1999; 52:100-108.

Ernst T, Chang L, Witt M, Walot I, et al. Progressive multifocal leukoencephalopathy and HIV-associated white matter lesions in AIDS: Magnetization transfer MR imaging. Radiology 1999; 210:539-543.

Ernst T, Chang L, Walot I, Huff K. Physiologic MRI of a tumefactive multiple sclerosis lesion. Neurology 1998;51:1486-88.

Speck O, Chang L, Itti L, Itti E, Ernst T. Comparison of Static and Dynamic Perfusion MRI Techniques for the Measurement of Regional Cerebral Blood Volume. Magn Reson Med 1999; 41:1264-1268 (1999).

Ernst T, Speck O, Itti L, Chang L. Simultaneous Correction for Interscan Patient Motion and Geometric Distortion in Echo Planar Imaging. Magn Reson Med 1999; 42:201-205 (1999).

Chang L, Ernst T, Speck O, Leonido-Yee M. Perfusion MRI Detects rCBF Abnormalities in Early Stages of HIV-Cognitive Motor Complex. Neurology 2000; 54:389-396.

Ernst T, Chang L, Leonido-Yee M, Speck O. Evidence for Long-Term Neurotoxicity Associated with Methamphetamine Abuse: A 1H MRS Study. Neurology 2000; 54:1344-1349.

Ernst T, Chang L, Oropilla G, Gustavson A, Speck O. Cerebral Perfusion Abnormalities in Abstinent Cocaine Abusers: A Perfusion MRI and SPECT Study. Psychiatry Research: Neuroimaging, 2000; 99: 63-74.

Speck O, Chang L, DeSilva M, Ernst T. Perfusion MRI of the Human Brain with Dynamic Susceptibility Contrast: Gradient Echo versus Spin Echo Techniques, J Magn Reson Imaging 2000; 12:381-387.

Ernst T, Itti E, Itti L, Chang L. Changes in Cerebral Metabolism are Detected Prior to Perfusion Changes in Early HIV-CMC: A Coregistered 1H MRS and SPECT Study, J Magn Reson Imaging 2000;12:859-865.

Smith LM, Chang L, Yonekura ML, Grob C, Osborn D, Ernst T, Brain Proton Magnetic Resonance Spectroscopy in Children Exposed to Methamphetamine In Utero, Neurology 2001; 57:255-260.

Speck O, Ernst T, Chang L. Multi Gradient Echo Acquisition Techniques for fMRI: Advantages of Bi-Exponential Modeling. Magn Reson Med 45, 1116-1121 (2001).

Chang L, Speck O, Miller E, Braun A, Jovicich J, Itti L, Ernst T. Neural Correlates Of Attention And Working Memory Deficits In Patients With HIV-1. Neurology 57, 1001-1007 (2001).

Jovicich J, Peters RJ, Koch C, Braun J, Chang L, Ernst T, Brain Areas Specific for Attentional Load in a Motion Tracking Task, J Cognitive Neuroscience 13, 1048-1058 (2001).

Ernst T, Chang L, Cooray D, Salvador C, Jovicich J, Walot I, Boone K, Chlebowski R.T, The Effects of Tamoxifen and Estrogen on Brain Metabolism in Elderly Women, Journal of National Cancer Institute 94(8):592-7 (2002).

Chang L, Ernst T, Witt M, Ames N, Jocivich J, Speck O, Gaiefsky M, Walot I, Miller E. Relationships Among Cerebral Metabolites, Cognitive Function and Viral Loads in Antiretroviral-Naïve HIV Patients. NeuroImage 2002;17:1638-1648.

Ernst T, Chang L, Jovicich J, Ames N, Arnold S, Abnormal Brain Activation on Functional MRI in Cognitively Asymptomatic HIV Patients, Neurology 2002; 59: 1343-1349.

Tomasi D, Ernst T. Echo planar imaging at 4 Tesla with minimum acoustic noise. J Magn Reson Imaging 2003;18:128-30.

Ernst T, Chang L, Arnold S, Increased Glial Markers Predict Increased Working Memory Network Activation in HIV patients. NeuroImage 2003;19(4):1686-93.

Caparelli EC, Tomasi D, Arnold S, Chang L, Ernst T. “k-Space based summary motion detection for functional magnetic resonance imaging”. NeuroImage 2003 Oct;20(2):1411-8.

Keller M, Venkatraman TN, Thomas A, Deveikis A, LoPresti C, Hayes J, Berman N, Walot I, Padilla , Johnston-Jones J, Ernst T, Chang L. Altered Neurometabolite Development in HIV-infected Children: Correlation with Neuropsychological Tests. Neurology 2004; 62:1810-1817.

Chang L, Arnold S, Tomasi D, Caparelli EC, Zimmerman L, Cloak C, Ernst T. Adaptation of the Attention Network in Human Immunodeficiency Virus Brain Injury. Annals of Neurology 2004;56:259-272.

Zhong K, Ernst T, Localized In Vivo Human 1H MRS at Very Short Echo Times, Magn Reson Med 52(4):898-901 (2004).

Cloak C, Chang L, Ernst T. Increased Frontal White Matter Diffusion is Associated with Glial Metabolites and Psychomotor Slowing in HIV. Journal of Neuroimmunology 2004;157(1-2):147-152.

Wang GJ, Chang L, Volkow ND, Telang F, Logan J, Ernst T, Fowler J. Decreased brain dopamine transporters in patients with HIV-associated dementia. Brain 2004 Nov;127(Pt 11):2452-8.

Chang L, Ernst T, Speck O, Grob C. Additive Effects of HIV and Chronic Methamphetamine Use on Brain Metabolite Abnormalities. American Journal of Psychiatry 2005;162(2):1-9.

Tomasi D, Chang L, Caparelli EC, Telang F, Ernst T. Acoustic noise interferes with working memory in HIV-patients. Annals of Neurology (in press).

Kim J, Zhu W, Chang L, Bentler PM, Ernst T. Multi-Subject, Multivariate Path Analysis of Functional MRI Data. Human Brain Mapping (in revision).

Ongoing Research Topics








University of Hawaii | John A. Burns School of Medicine | The Queen's Medical Center

Last Updated: April 2010
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