University of Hawaii Neuroscience and MRI Research Program

Research Topics

Neurodevelopment


“Development of quantitative MRI DTI analysis tool for preterm neonate"

(Subaward from Johns Hopkins University PI, K. Oishi, Ph.D.; site-PI, Linda Chang, M.D.; funding source: NICHD - 1R01 HD065955; Project Period: 09/20/11 – 07/31/16)

The proposed study aims to create a multi-contrast atlas of the neonatal brain along with related tools for quantitative analyses of brain structural differences between preterm and term born neonates. Such an atlas will be a very useful resource as it will allow precise evaluation of brain abnormalities in premature babies that could ultimately inform early interventions and improve outcome. The infants are all scanned in Hawaii and the data are transferred to the Johns Hopkins University for image analyses and atlas development.

Contact:
Robyn Yamakawa - phone: (808) 691-8964; email: robyn hy-AT- hawaii -DOT- edu

Sara Hayama - phone: (808) 691-8962; email: a v b hernandez -AT- gmail -DOT- com

Creating a Pediatric Imaging-Genomics Data Resource"

(Multi-site with mutliple PIs: T.Jernigan, A. Dale, L. Chang, T. Ernst, & S.Murray; funding source: NIDA - 5RC2 DA029475; Project Period: 09/30/09 – 08/31/13)

This was a multi-site collaborative effort to study how genes might influence brain development (using MR techniques). More than 100 typically developing children across 910 sites (U Hawaii, UCSD, UCLA, USC, UC Davis, Cornell, Yale, MGH, U Mass, and Johns Hopkins) were enrolled in the study. Subject enrollment is now complete; analyses of data collected are ongoing. A data resource which includes neurodevelopmental histories, brain imaging data, genotypes is available to qualified researchers (http://pingstudy.ucsd.edu).

Contact:
Kristin Lee - phone: (808) 586-7459; email: kristen m lee 72-AT- gmail -DOT- edu

Vanessa Douet, Ph.D. - phone: (808) 586-7468; email: douet -AT- hawaii -DOT- edu

"Creating a Pediatric Imaging-Genomics Data Resource "Psychosis candidate variants in the NRG1-ERBB4 pathway on brain trajectories"
"

(Original study PIs: T. Jernigan, A. Dale, L. Chang, T. Ernst, & S. Murray; funding source: NIDA - 5RC2 DA029475; Project Period: 09/30/09 – 08/31/13) This was a multi-site collaborative effort to study how genes might influence brain development (using MR techniques). More than 1000 typically developing children across 9 sites (U Hawaii, UCSD, UCLA, UC Davis, Cornell, Yale, MGH, U Mass, and Johns Hopkins) were enrolled in the study. Subject enrollment is now complete; analyses of data collected are ongoing. A data resource which includes  neurodevelopmental histories, brain imaging data, genotypes is available to qualified researchers (http://pingstudy.ucsd.edu).

This sub-study (PI V.Douet) will follow 50 of the 250 children enrolled in the original PING study here at the Hawaii site. It will determine how several genes related to neuropsychiatric disorders (e.g., schizophrenia, psychosis, drug abuse, addiction) influence brain development in typically developing adolescents, ages 10 to 25.

Contact:
Vanessa Douet, Ph.D. - phone: (808) 586-7468; email: douet -AT- hawaii -DOT- edu


All information and data obtained for the research are strictly confidential.








University of Hawaii | John A. Burns School of Medicine | The Queen's Medical Center

Last Updated: January 2014
For questions or to report problems, please email nmr -AT- hawaii -DOT- edu.
This website is part of the University of Hawaii Department of Medicine.