University of Hawaii Neuroscience and MRI Research Program

Research Topics

Neurodevelopment


“The ABCD Study: Adolescent Brain Cognitive Development Study"

(multi site with multiple site PI's supported by the National Institute On Drug Abuse of the National Institutes of Health; site-PIs, Linda Chang, M.D., Thomas Ernst, Ph.D,Thomas Wills, Ph.D.; funding source: RFA-DA-15-015 NIDA; Project Period: 09/30/2015 – 05/31/2020)

The ABCD Study is the largest long-term study of cognitive and brain development in children across the United States. 10,000 healthy children age 9-10 will be followed over 10 years.

In Hawaii, this study will follow ~1,000 children in Hawaii, through their adolescence.

The scientists will follow how the brain develops in these children with many different backgrounds (e.g., race, ethnicity), different temperaments, social and family environments.

The study can help us understand what factors may influence brain development, which could lead to prevention, treatment intervention, & public health strategies for mental and substance use disorders.

Contact:
Linda Chang, MD - phone: (808) 691-8969; email: lchang-AT- hawaii -DOT- edu

Vanessa Douet, Ph.D. - phone: (808) 586-7468; email: Vee Douet-AT- gmail -DOT- com

“Development of quantitative MRI DTI analysis tool for preterm neonate"

(Subaward from Johns Hopkins University PI, K. Oishi, Ph.D.; site-PI, Linda Chang, M.D.; funding source: NICHD - 1R01 HD065955; Project Period: 09/20/11 – 07/31/16)

The proposed study aims to create a multi-contrast atlas of the neonatal brain along with related tools for quantitative analyses of brain structural differences between preterm and term born neonates. Such an atlas will be a very useful resource as it will allow precise evaluation of brain abnormalities in premature babies that could ultimately inform early interventions and improve outcome. The infants are all scanned in Hawaii and the data are transferred to the Johns Hopkins University for image analyses and atlas development.

Contact:
Robyn Yamakawa - phone: (808) 691-8964; email: robyn hy-AT- hawaii -DOT- edu

Sara Hayama - phone: (808) 691-8962; email: a v b hernandez -AT- gmail -DOT- com

Creating a Pediatric Imaging-Genomics Data Resource"

(Multi-site with mutliple PIs: T.Jernigan, A. Dale, L. Chang, T. Ernst, & S.Murray; funding source: NIDA - 5RC2 DA029475; Project Period: 09/30/09 – 08/31/13)

This was a multi-site collaborative effort to study how genes might influence brain development (using MR techniques). More than 100 typically developing children across 910 sites (U Hawaii, UCSD, UCLA, USC, UC Davis, Cornell, Yale, MGH, U Mass, and Johns Hopkins) were enrolled in the study. Subject enrollment is now complete; analyses of data collected are ongoing. A data resource which includes neurodevelopmental histories, brain imaging data, genotypes is available to qualified researchers (http://pingstudy.ucsd.edu).

Contact:
Kristin Lee - phone: (808) 586-7459; email: kristen m lee 72-AT- gmail -DOT- edu

Vanessa Douet, Ph.D. - phone: (808) 586-7468; email: douet -AT- hawaii -DOT- edu

"Creating a Pediatric Imaging-Genomics Data Resource "Psychosis candidate variants in the NRG1-ERBB4 pathway on brain trajectories"
"

(Original study PIs: T. Jernigan, A. Dale, L. Chang, T. Ernst, & S. Murray; funding source: NIDA - 5RC2 DA029475; Project Period: 09/30/09 – 08/31/13) This was a multi-site collaborative effort to study how genes might influence brain development (using MR techniques). More than 1000 typically developing children across 9 sites (U Hawaii, UCSD, UCLA, UC Davis, Cornell, Yale, MGH, U Mass, and Johns Hopkins) were enrolled in the study. Subject enrollment is now complete; analyses of data collected are ongoing. A data resource which includes  neurodevelopmental histories, brain imaging data, genotypes is available to qualified researchers (http://pingstudy.ucsd.edu).

This sub-study (PI V.Douet) will follow 50 of the 250 children enrolled in the original PING study here at the Hawaii site. It will determine how several genes related to neuropsychiatric disorders (e.g., schizophrenia, psychosis, drug abuse, addiction) influence brain development in typically developing adolescents, ages 10 to 25.

Contact:
Vanessa Douet, Ph.D. - phone: (808) 586-7468; email: douet -AT- hawaii -DOT- edu


All information and data obtained for the research are strictly confidential.








University of Hawaii | John A. Burns School of Medicine | The Queen's Medical Center

Last Updated: January 2014
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